Nitric Oxide (NO) has numerous benefits for wound healing but has challenges associated with its delivery. Several companies are addressing those challenges and creating an exciting opportunity in wound care.
Nitric oxide (NO) was named “Molecule of the Year” by the journal Science in 1992, and six years later, three US scientists were awarded the Nobel Prize for Physiology and Medicine for their efforts to prove that NO, an endogenous gas and free radical, could have crucial biological effects. One of the well-known medical uses of NO is via nitroglycerin, a precursor to NO, to prevent and treat chest pain (angina). It works by relaxing blood vessels, which decreases the amount of work the heart has to do. NO has been identified for its value in chronic wound healing for many years because of its function in vasodilation, relaxing blood vessels and increasing blood flow, as well as its broad-spectrum antimicrobial and antibiofilm activity.
No products have yet reached the market for chronic wounds; however, SmartTRAK has noted increasing activity related to the benefits of NO for wound healing. In fact, an article was published earlier this year entitled “Emerging Strategies for Nitric Oxide Production and Their Topical Application as Nano Dressings to Promote Diabetic Wound Healing.” The article identified four primary modes in which NO benefits the diabetic wound healing process: providing antimicrobial properties, promoting angiogenesis, regulating inflammation and promoting tissue regeneration and remodeling.
This market outlook article will discuss in detail the following subjects:
- The Challenge
- Research has shown that when NO is appropriately activated and sustained in the body, it improves oxygen and nutrient delivery and is anti-pathogenic, aiding in the wound healing process. Several years ago, 3M (now Solventum) researchers published an article, “Nitric oxide levels in wound fluid may reflect the healing trajectory,” in which their data analysis demonstrated that ... (read more)
- Clinical and Commercial Activity in Companies Closest to Bringing a NO-Based Product to Market
- Convatec acquired 30 Technology’s wound care platform and developed a NO-generating technology platform representing a ... (read more)
- NOxy Health is pursuing full IND approval, driven by the potential to unlock a broader set of indications ... (read more)
- Nytricx received funding to develop a dressing that provides homeostasis in ... (read more)
- A Surge in Intellectual Property
- SmartTRAK monitors published and issued patents on a daily basis. Smart dressings and negative pressure wound therapy devices have dominated the intellectual property activity. Following is a list of recently published or issued patents related to the use of nitric oxide in wound care ... (read more)
Interested in the future for NO in wound healing? Click the button below to read the complete "Is Nitric Oxide the Next Big Thing in Wound Care?" article by Susan Paquette, SmartTRAK Senior Advisor, Wound.
SmartTRAK is the Medtech industry’s only global Insights-as-a-Service solution for the Orthopedics, Wound Care, Regenerative Medicine and Neuro Therapy markets. SmartTRAK’s proprietary methodology turns disparate data from hundreds of sources into powerful insights customers can rely on as the trusted source for strategic decision-making. The SmartTRAK enterprise platform includes rich daily updates, comprehensive market coverage and simple-to-use tools and dashboards for market, product and financial analysis. Customers leveraging the SmartTRAK platform also have direct access to market experts for inquiries and advisory services. If you would like a demo of what SmartTRAK has to offer and see how we can help increase proficiency, improve productivity and reduce costs for your company, just click here.
