KECK Medicine of USC has published a preclinical study demonstrating the potential of a new opioid medication that may slow OA progression while being less addictive. The therapy MOA is kappa opioid receptor (KOR) modulation via inhibition of hedgehog signaling. Arthritis Rheum
A 200-pt prospective, case-control study is underway to assess if the presence of gene polymorphisms (1575 G/A MMP-2, 836 A/G MMP-9 and -77 A/G MMP-13) in the metalloproteinases (MMPs) affect the risk of developing idiopathic kOA in the Greek population. clinicaltrials.gov
An insurance database review w/ 41,467 primary RCR pts (41,844 shoulders) showed 52.7% male, 60-69 yrs of age most prevalent (~38%) and 8.38% revision rate. Revision risk factors were increasing age, male sex, smoking, obesity, hyperlipidemia and vitamin D deficiency. Arthroscopy
This article reviews the challenges of revision surgery and the conversion from implants to arthrodesis, emphasizing the need for bone grafting for optimal results. Clinics in Podiatric Med & Surg
According to a 22-pt study, only 41% of pts undergoing biologically enhanced (PRP and BMAC) patch augmentation RC repair reached substantial clinical benefit, whereas 32% reached or exceeded the PASS criteria. Arthroscopy
In Q120, Aurora Spine finalized product designs for a Posterior SI Joint fusion product made from SILO (cortical allograft) and the ZIP-Flex interlamar fixation device. The product is expected to hit the market later this year or 2021.
A claims database review of 284 pts who underwent MAT reported 167 pts (58.8%) underwent reoperation at an average of 11.9 mos post-op. UKA and TKA conversion rates were 0.7% and 1.1%, respectively. The overall 30-day complication rate following MAT was 1.4%. Arthroscopy
US Patent "Synthetic block intended for filling in a bone defect and method for manufacturing same" was granted. 10,639,156
MiMedx announced that as part of the private equity financing, EW Healthcare Partners has designated Managing Director & Co-Founder Martin Sutter and former Medtronic Chairman & CEO William Hawkins III to serve on MiMedx’s board as preferred Directors.
A 30-pt study is underway to evaluate arthroscopic double-beam anatomical reconstruction of the medial patellofemoral ligament for recurrent patellar dislocation. The anticipated completion date is 12/1/22. clinicaltrials.gov
Union rates vary for arthrodesis sites and bone healing in foot and ankle surgery. This article discusses bone grafting and orthobiologics and how they modify the healing environment. Clinics in Podiatric Med & Surg
A systematic review and meta-analysis of 25 studies w/ 439 pts reported no significant difference in pain improvement between MSC treatment and controls. Cartilage volume improved after MSC tx and MSC therapy showed better functional improvement. Arthroscopy
Of the MACI cases canceled in H120 due to the COVID-19 pandemic, ~70% have been rescheduled, w/ over 50% of the canceled cases completed by the end of Q220.